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系統介紹

FreezeScan(CleverSys, Inc., CSI)是Gene&I聯(lián)合CleverSys推出的進(jìn)行條件性恐懼實(shí)驗的分析系統?？梢苑治鲈谝粋€(gè)固定的活動(dòng)箱內任意角度的視頻文件，它可以精確分析嚙齒類(lèi)動(dòng)物恐懼行為的發(fā)生和結束。

FreezeScan(CleverSys, Inc., CSI)不僅可以精確地監測動(dòng)物恐懼行為，還可以在實(shí)驗過(guò)程中以數字和圖形的形式提供精確地動(dòng)物瞬時(shí)活動(dòng)度水平，使震驚反應研究成為可能。

除此之外，通過(guò)額外的實(shí)驗硬件，還可以進(jìn)行動(dòng)物共情行為的研究。

系統特點(diǎn)

●  全功能條件性恐懼行為分析系統

●  主控機可同時(shí)控制64個(gè)裝置

●  活動(dòng)度測量可進(jìn)行震驚反應研究

●  高通量模式可同時(shí)進(jìn)行4個(gè)活動(dòng)箱內的實(shí)驗

●  實(shí)時(shí)分析功能和錄像后分析功能

●  自動(dòng)監測視頻中視覺(jué)信號的開(kāi)關(guān)（如LED燈）

●  可進(jìn)行多種時(shí)間間隔設置

●  自動(dòng)生成時(shí)間間隔數據

●  簡(jiǎn)易雙擊回放功能

Reference

I-Ting Judy Wang, Megan Allen, Darren Goffin, Xinjian Zhu, Andrew H. Fairless, Edward S. Brodkin, Steve J. Siegel, Eric D. Marsh, Julie A. (2012) Blendy, and ZhaolanZhou ,(2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice, PNAS, Dec 2012; 109: 21516 – 21521.

Lin H-C, Gean P-W, Wang C-C, Chan Y-H, Chen PS (2013) The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model. PLoS ONE 8(1): e55248. doi:10.1371/journal.pone.0055248.

Sotres-Bayon, Francisco; Sierra-Mercado, Demetrio; Pardilla-Delgado, Enmanuelle; Quirk, Gregory??J. (2012) Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs, Neuron doi:10.1016/j.neuron.2012.09.028 (volume 76 issue 4 pp.804 - 812).

Kristen A. Rahn, Crystal C. Watkins, Jesse Alt, Rana Rais, MarigoStathis, Inna Grishkan, Ciprian M. Crainiceau, Martin G. Pomper, Camilo Rojas, Mikhail V. Pletnikov, Peter A. Calabresi, Jason Brandt, Peter B. Barker, Barbara S. Slusher, and Adam I. Kaplin, (2012) Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis, PNAS 2012; doi:10.1073/pnas.1209934109.

Pushpinder K. Multani, Rachel Hodge, Marcel A. Estévez, Ted Abel, Hank Kung, Mark Alter, Bethany Brookshire, Irwin Lucki, Aleksandra H. Nall, Konrad Talbot, Glenn A. Doyle, Falk W. Lohoff, (2012) VMAT1 Deletion Causes Neuronal Loss in the Hippocampus and Neurocognitive Deficits in Spatial Discrimination, Neuroscience Available online 28 November 2012.